A theoretical approach to select effective antisense oligodeoxyribonucleotides at high statistical probability
نویسندگان
چکیده
منابع مشابه
A theoretical approach to select effective antisense oligodeoxyribonucleotides at high statistical probability.
Up to now, out of approximately 20 antisense oligodeoxyribonucleotides (as ODN) selected and tested against a given target gene, only one species shows substantial suppression of target gene expression. In part, this seems to be related to the general assumption that the structures of local target sequences or antisense nucleic acids are unfavorable for efficient annealing. Experimental approac...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1999
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/27.22.4328